By European Society of Cardiology
April 28, 2021

Heart Cardiology Concept

Omega-3 supplements are related to an increased possibility of establishing atrial fibrillation in individuals with high blood lipids. That’s the finding of a research study released today in European Heart Journal– Cardiovascular Pharmacotherapy, a journal of the European Society of Cardiology (ESC).[1]

” Currently, fish oil supplements are shown for clients with raised plasma triglycerides to minimize cardiovascular threat,”[2] stated research study author Dr. Salvatore Carbone of Virginia Commonwealth University, United States. “Due to the high occurrence of raised triglycerides in the population, they can be frequently recommended. Of note, low dosage omega-3 fats are readily available nonprescription, without the requirement for a prescription.”

Some scientific trials have actually recommended that omega-3 fats might be related to an increased threat for atrial fibrillation, the most typical heart rhythm condition. Individuals with the condition have a 5 times higher probability of having a stroke.[3]

Omega-3 Fish Oil Supplements

These research studies evaluated various formulas of omega-3 fats at various dosages. The authors for that reason carried out an extensive meta-analysis of randomized regulated trials to respond to the concern of whether fish oils were regularly associated to a raised danger for atrial fibrillation.

The analysis consisted of 5 randomized regulated trials examining the impacts of omega-3 fatty acid supplements on cardiovascular results. Individuals had raised triglycerides and were either at high danger for heart disease or had actually developed heart disease. An overall of 50,277 clients got fish oils or placebo and were followed up for in between 2 and 7.4 years. The dosage of fish oils differed from 0.84 g to 4 g daily.

The scientists discovered that omega-3 fat supplements was connected with a considerably increased danger for atrial fibrillation compared to placebo with an occurrence rate ratio of 1.37(95%self-confidence period 1.22 -1.54; p

Dr. Carbone stated: “Our research study recommends that fish oil supplements are related to a substantially higher danger of atrial fibrillation in clients at raised cardiovascular threat. One medical trial showed helpful cardiovascular impacts of supplements,[4] the danger for atrial fibrillation must be thought about when such representatives are recommended or bought over the counter, specifically in people vulnerable to establishing the heart rhythm condition.”


  1. ” Omega-3 fats supplements and danger of atrial fibrillation: an upgraded meta-analysis of randomized regulated trials” by Lombardi M, Carbone S, Del Buono MG, et al., 29 April 2021, European Heart Journal– Cardiovascular Pharmacotherapy
    DOI: 10.1093/ ehjcvp/pvab008
  2. Mach F, Baigent C, Catapano AL, et al. 2019 ESC/EAS Standards for the management of dyslipidaemias: lipid adjustment to decrease cardiovascular danger. Eur Heart J. 2020;-LRB- : 111-188
  3. Hindricks G, Potpara T, Nikolaos Dagres N, et al. 2020 ESC Standards for the medical diagnosis and management of atrial fibrillation established in cooperation with the European Association of Cardio-Thoracic Surgical Treatment (EACTS). Eur Heart J. 2020.
    DOI: 10.1093/ eurheartj/ehaa612
  4. Bhatt DL, Steg PG, Miller M, et al. Cardiovascular threat decrease with icosapent ethyl for hypertriglyceridemia. N Engl J Medication. 2019;-LRB- : 11-22


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